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Von Willebrand disease inheritance

The Inheritance of von Willebrand Disease > Genetics > HoG

Inheritance Patterns of VWD von Willebrand Diseas

VWD inheritance - Haemophili

  1. Von Willebrand disease Von Willebrand disease (VWD) is a common inherited condition that can make you bleed more easily than normal. People with VWD have a low level of a substance called von Willebrand factor in their blood, or it does not work very well. Von Willebrand factor helps blood cells stick together (clot) when you bleed
  2. ant), the clinical and laboratory severity of the disease varies considerably
  3. Von Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII (FVIII) in the circulation. Therefore, defects in VWF can.
  4. Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot well. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should. Most people with the disease are born with it, having inherited it from one or both parents
  5. Von Willebrand disease (VWD) is a common inherited bleeding disorder in the general population affecting males and females equally, but women may be disproportionately impacted due to the bleeding challenges of menstruation and childbirth

Von Willebrand disease is inherited as an autosomal recessive trait (Lillicrap, 2009). Autosomal recessive inheritance of VWD was described by several authors, including Veltkamp and van Tilburg (1974), Holmberg (1974), Sultan et al. (1975), Ruggeri et al. (1976), and Ingram (1978) A large number of patients with VWD inherit the disease according to classic Mendelian genetics. Although VWD type 1 and 2 are generally inherited in an autosomal-dominant pattern, VWD type 3 is inherited in an autosomal-recessive pattern Von Willebrand disease (VWD), the most common inherited bleeding disorder, is due to either a quantitative or qualitative abnormality of von Willebrand factor (VWF). VWF provides the critical link between platelets and exposed vascular subendothelium, and also binds and stabilizes coagulation factor VIII von Willebrand disease (vWD) is the most common inherited disorder of hemostasis and comprises a spectrum of heterogeneous subtypes. Significant advances have been made in understanding von Willebrand factor (vWF) gene mutations, resultant physiologic deficits in the vWF peptide, and their correlation to clinical presentation.Diagnostic tests for this disorder are complex, and interpretation.

Von Willebrand disease is the most common inherited bleeding disorder. It is characterized clinically by mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. The disorder results from a defect in platelet aggregation due to defects in the von Willebrand factor protein Von Willebrand disease and hemophilia, two conditions that are most often inherited, may also develop as a result of a medical condition. Other, rarer types of acquired bleeding disorders include deficiencies of certain factors, such as factor I, II, and V, that are named for the clotting factor causing the problem Canine Von Willebrand's Disease: Inheritance Expression and inheritance patterns of von Willebrand's disease differ from one dog to another. Generally, all males and females have two von Willebrand's factor genes. The presence of one abnormal von Willebrand's factor gene appears sufficient to cause unusual bleeding in some dogs Von Willebrand Disease (VWD) is considered to be the most common bleeding disorder in humans and in some animals such as dogs. VWD is named after the Finnish physician who described the disease in the 1920s. 1 in 100 to 10 000 individuals in estimated to have VWD. Patients with mild VWD symptoms are rarely diagnosed resulting in the gap 100 to 10 000[1]

Diagnosis of inherited von Willebrand disease: a clinical

  1. iature schnauzers, golden retrievers, Scottish terriers, Doberman.
  2. e the type, but additional molecular genetic testing may be.
  3. Introduction. von Willebrand disease (VWD) is the most common inherited bleeding disorder. 1,2 Despite this, VWD is one of the most commonly misdiagnosed or overlooked entities in everyday clinical practice. Of interest, VWD may be both over- and under-diagnosed, as well as misdiagnosed, either as another entity or as a different subtype of the disorder
  4. von Willebrand Disease (abbreviated vWD) is an inherited bleeding disorder caused by lack of von Willebrand factor protein (vWF). This protein circulates in the blood stream and must be present at the site of blood vessel injury in order to control bleeding from that vessel. Von Willebrand disease is a distinct disorder, it is not hemophilia

Inheritance and prevalence of von Willebrand's disease severe form in a Brazilian population. Fischer RR(1), Lerner C, Bandinelli E, Fonseca AS, Roisenberg I. Author information: (1)Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil Von Willebrand disease (vWD) is the most common inherited genetic bleeding disorder, yet it is not well known or understood among the public or healthcare providers. Von Willebrand factor (vWF) is a protein that is essential for platelet aggregation and clotting. A low vWF can lead to heavy or prolonged bleeding Von Willebrand disease (vWD) is the most common inherited bleeding disorder. The prevalence of symptomatic vWD is approximately 0.01%. Identification of milder forms is complicated by the broad range of von Willebrand factor (vWF) levels in the normal population; it is important to recognize that the diagnosis of vWD requires the presence of. Von Willebrand disease (VWD) is the most common inherited bleeding disorder, characterized by an extreme variability of clinical manifestations and laboratory phenotypes. The clinical spectrum varies from subjects with dubious, mild symptoms to patients with spontaneous, severe, sometimes life-threatening bleeds

Von Willebrand disease. Von Willebrand disease (vWD) is the most common inherited bleeding disorder. The prevalence of symptomatic vWD is approximately 0.01%. Identification of milder forms is complicated by the broad range of von Willebrand factor (vWF) levels in the normal population; it is important to recognize that the diagnosis of vWD. Plasma von-Willebrand-factor changes during various reproductive cycle stages in mixed-breed dogs with normal von-Willebrand-factor and in Doberman Pinschers with type-I von-Willebrands-disease American Journal of Veterinary Research 59:111-118, 1998. Pubmed reference: 9442254

Von Willebrand disease is the most common inherited bleeding disorder among American women, with a prevalence of 0.6-1.3% 1.The overall prevalence is even greater among women with chronic heavy menstrual bleeding, and ranges from 5% to 24% 2 3.Among women with heavy menstrual bleeding, von Willebrand disease appears to be more prevalent among Caucasians (15.9%) than African Americans (1.3%) 3 4 Menorrhagia is a common symptom of von Willebrand disease.8, 9 von Willebrand disease is a genetic condition characterized by a reduction in the quantity (type I or type III) or quality (type II) of von Willebrand factor, a protein required for normal blood clotting.10 Type I is the mildest and most common form of the disease and may affect 1. Autosomal Dominant Inheritance of Von Willebrand Disease Genogram. School project for a genetics class. A genogram (also known as a McGoldrick-Gerson study, a Lapidus schematic, or a family diagram) is a pictorial display of a person's family relationships and medical history

Description. Von Willebrand disease is the most common inherited bleeding disorder. It is characterized clinically by mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. The disorder results from a defect in platelet aggregation due to defects in the von Willebrand factor protein Find out about Von Willebrand disease, an inherited bleeding disorder that affects up to one in 100 people. Read more on myDr website. von Willebrand disease - Haemophilia Foundation Australia. Information about von Willebrand disorder or disease (VWD), how common it is, how it is passed on, inheritance and treatment..

Inheritance and prevalence of von Willebrand's disease

  1. g AM, Collins PW, Hill FG. Br J Haematol, (1):91-96 2006 MED: 1692579
  2. Von Willebrand Disease (VWD) is an inherited bleeding disorder caused by an abnormal blood-clotting protein called von Willebrand Factor (VWF). The VWF is important for the body to create the first steps of a blood clot to stop bleeding with injury and surgery. It's particularly important for helping to making needed blood clots when one has.
  3. Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It occurs in approximately 1% of the population, including more than 3 million people in the US alone. Learn more about signs, symptoms and diagnosis
  4. To seek an explanation, we studied 5 severe bleeder aortic stenosis patients in a cohort of 49 patients, using the flowchart for inherited von Willebrand disease. Approach and Results: All 5 patients were lacking in large and intermediate VWF (von Willebrand factor) multimers, 3 had reduced plasma and platelet VWF levels, and none showed PFA100.
  5. imizing stress as much.
  6. Von Willebrand disease is a genetic disease that occurs when there is a change within the gene that makes von Willebrand factor. Von Willebrand disease can be inherited from a parent or, in rare cases, from both parents. The gene for von Willebrand disease is located on chromosome 12, and it can affect men and women

Von Willebrand disease (VWD) is an inherited disorder that affects the blood's ability to clot Von Willebrand disease (VWD) is an inherited condition that affects the blood's ability to clot effectively. It is a very common bleeding disorder that affects girls and boys equally. When a person gets a cut, a type of cell in the blood called a platelet, and a protein called von Willebrand factor (VWF), stick to the wound to plug the cut

Abstract: von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral. E.J. Favaloro, in Reference Module in Biomedical Sciences, 2014 Abstract. von Willebrand disease (or disorder; VWD) is the most common inherited bleeding disorder. VWD can also arise as an acquired event, where it is termed acquired von Willebrand syndrome (AVWS). VWD arises from deficiency, and/or defects, in the plasma protein von Willebrand factor (VWF), and is distinct from hemophilia A. Von Willebrand Disease is the most common inherited bleeding disorder in which von Willebrand factor (vWF), a blood protein, is either deficient or defective. Von Willebrand factor is a glue-like protein that interacts with platelets to form a plug which prevents the blood from flowing at the site injury

Von Willebrand disease (vWD) is the most common inherited disorder of hemostasis in both humans and dogs. It is due to a deficiency or abnormality in von Willebrand factor (vWf). Production of vWf. Von Willebrand factor is a large multimeric glycoprotein that circulates non-covalently with Factor VIII coagulant protein Von Willebrand disease is a bleeding disorder resulting from a defect in platelet aggregation due to defects in the von Willebrand factor protein. Type 3 von Willebrand disease, which is inherited as an autosomal recessive disorder, is associated with a severe quantitative defect or virtual absence of VWF in plasma, a prolonged bleeding time. Chapter 10: Von Willebrand disease Von Willebrand disease (VWD) is the most common inherited bleeding disorder with 1 in 20,000 people being affected (Favaloro, 2017). The disease is caused by a lack of the Von Willebrand factor (VWF), a clotting factor that has multiple to functions: being a carrier for coagulation factor 8 (FVIII) an What is von Willebrand's disease? Von Willebrand's disease (vWD) is the most common inherited bleeding disorder of both humans and dogs. It is caused by a deficiency in the amount of a specific protein needed to help platelets (the blood cells used in clotting) stick together and form clots to seal broken blood vessels. The deficient protein is called von Willebrand factor (vWF)

Von Willebrand disease is a lifelong disorder that is often inherited. This disease causes improper blood clotting, which can cause potentially serious and abnormal bleeding after an accident, trauma, surgery or dental work.. Nosebleeds, blood in the urine or stool and bruising are also common with von Willebrand disease Von Willebrand disease (VWD) can be inherited or acquired. Inherited phenotypic forms of Von Willebrand disease are: Type 1: This is an autosomal dominant disease (AD, incomplete penetrance approximately 60%) and is caused by a partial quantitative deficiency of von Willebrand factor Most commonly inherited bleeding disorder, first described in Aland Islands by Erik von Willebrand. It occurs as a result of decrease in plasma levels or defect in von Willebrand factor which is a.

Heredity of von Willebrand disease | Hemophilia

Autosomal inheritance with variable penetrance and phenotypic expression. Usually presents with mucocutaneous bleeding. Menorrhagia and postnatal haemorrhage common in affected females. Joint bleeding rare and seen only in patients with more severe disease. Most patients have type 1 von Willebran.. Introduction to von Willebrand Disease. von Willebrand disease (vWD) is caused by deficiencies in the protein von Willebrand factor (vWF). vWF is a multi-subunit glycoprotein that is found in subendothelial connective tissue, the blood and in the α granules of platelets. vWD and vWF get their name from Erik von Willebrand who first described a bleeding disorder whose mode of inheritance was. Von Willebrand Disease is a genetic bleeding disorder where patients have a deficient or defective von Willebrand factor (VWF), a protein in the blood that is important for clot formation. While there is no cure for VWD, there are treatment options. 1. When a blood vessel is injured and bleeding occurs in people with VWD, it takes longer for. Von Willebrand disease (VWD) is the most common inherited bleeding disorder worldwide with an overall prevalence of 1% and approximately 1.1% in the USA [1] [2]. VWD is due either to the deficiency or abnormal function of Von Willebrand factor (VWF) [3]. Its inheritance is usually autosomal dominant [2]

Von Willebrand disease Genetic and Rare Diseases

  1. ant pattern. This means only a single copy of an abnormal gene in each cell can cause the disease. Rarely, individuals may inherit type 2 and type 1 in an autosomal recessive.
  2. In 1926, Dr. Erik von Willebrand, a Finnish physician, published the first description of an inherited bleeding disorder that was different from hemophilia. Dr. von Willebrand's studies into this new disease began with a family living on the island of Föglö in the Åland archipelago in the Baltic Sea
  3. Chapter 10: Von Willebrand disease Von Willebrand disease (VWD) is the most common inherited bleeding disorder with 1in 20,000 people being affected (Favaloro, 2017). The disease is caused by a lack of the VonWillebrandfactor (VWF), a clotting factor that has multiple to functions: being a carrier for coagulation factor 8 (FVIII) andallowing platelets to clump [
  4. von Willebrand disease (VWD) is characterized by its heterogeneous clinical manifestation, which complicates its diagnosis and management. The clinical management of VWD has remained essentially unchanged over the last 30 years or so, using von Willebrand factor (VWF) concentrates, desmopressin, and anti-fibrinolytic agents as main tools to control bleeding

What is von Willebrand Disease? CD

What is von Willebrand disease? 1 von Willebrand disease (VWD) is a bleeding disorder. People with VWD have a problem with a protein in their blood that helps control bleeding. They do not have enough of the protein or it does not work the way it should. It takes longer for blood to clot and for bleeding to stop. There are different types of VWD Von Willebrand Disease is usually an inherited condition and is passed down from parent to child. While there is currently no way to entirely treat or prevent Von Willebrand's disease, home remedies can help to treat the symptoms. Types of Von Willebrand Disease. There are three types of VWD, these ar The inheritance of type I von Willebrand's disease is thought to be autosomally dominant. The laboratory profile may, however, vary between affected people, even within a single family. There is also a large variation in the severity of clinical symptoms Definition, Etiology, PathogenesisTop. Von Willebrand disease (vWD) is the most frequent inherited bleeding disorder. It is caused by a deficiency or dysfunction of von Willebrand factor (vWF), which affects both primary and secondary hemostasis (vWF is a cofactor in the adhesion of platelets to the exposed subendothelium and protects factor VIII from inactivation) Von Willebrand disease can be more complicated for women because of obstetric and gynecological issues. Inheritance Pattern. Like hemophilia, the disease is passed down through the genes. But unlike hemophilia, which usually affects only males, von Willebrand disease occurs in men and women equally

Objective—To determine the mode of inheritance of von Willebrand's disease (vWD) and perform linkage analysis between vWD and coat color or narcolepsy in a colony of Doberman Pinschers.. Animals—159 Doberman Pinschers.. Procedure—von Willebrand factor antigen (vWF:Ag) concentration was measured by use of ELISA, and results were used to classify dogs as having low (< 20%), intermediate. Acquired von Willebrand syndrome (AVWS) is a bleeding disorder that can occur due to a variety of conditions, but is not caused by a VWF gene mutation.It is most often seen in persons over age 40 years with no prior bleeding history. This condition may result from lymphoproliferative disorders, autoimmune disorders (including systemic lupus erythrematosus, scleroderma, and antiphospholipid. Von Willebrand disease and inherited platelet function disorders are considered uncommon causes of bleeding disorders. But these disorders are not as uncommon as perceived. In this study, 31.1% of the 2,800 patients of bleeding disorders were diagnosed with inherited platelet function disorders and/or inherited coagulation factor deficiencies Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising • Skin bleeding • Prolonged bleeding from mucosal surfaces (oropharyngeal, GI. uterine) Laboratory • Normal platelet count (mild thrombocytopenia in type 2B) • Normal PT/INR • Normal aPTT (prolonged if very low factor VIII) Treatment • Desmopressin (DDAVP) #VonWillebrand #Disease #Diagnosis. Three intragenic restriction fragment length polymorphisms (RFLPs) were used to study linkage and analyse the mode of inheritance in type I and type III von Willebrand's disease (VWD). In two families linkage was established between Sac I RFLPs and the inheritance of type I vWD. RFLP analysis of amniocyte DNA from a potentially affected foetus enabled us to establish a prenatal diagnosis of.

Von Willebrand disease (vWD) is the commonest inherited bleeding diathesis but may be acquired. Clinical presentation Bruising and mucosal bleeding are typical presentations, but there is a spectrum of severity. The more residual von Willebrand.. Autosomal inheritance with variable penetrance and phenotypic expression. Usually presents with mucocutaneous bleeding. Menorrhagia and postnatal haemorrhage common in affected females. Joint bleeding rare and seen only in patients with more severe disease. Most patients have type 1 von Willebran..

Von Willebrand disease - Wikipedi

Von Willebrand disease (VWD) is the most common inherited bleeding disorder with 1 in 20,000 people being affected (Favaloro, 2017). The disease is caused by a lack of the Von Willebrand factor (VWF), a clotting factor that has multiple to functions: being a carrier for coagulation factor 8 (FVIII) and allowing platelets to clump and aggregate. Inheritance of Von Willebrand disease, recessive form. Genetic and familial features of the condition may include: 2 Genetics of Von Willebrand Disease, Recessive Form: Autosomal recessive inheritance Genetics. Read more about genetics of related diseases

Wilson&#39;s disease - Symptoms and causes - Mayo Clinic

Von Willebrand disease (VWD) is the most frequent inherited bleeding disorder and is due to quantitative (types 1 and 3) or qualitative (type 2) defects of von Willebrand factor (VWF). VWD is inherited by autosomal dominant or recessive patterns, but women with mild forms are more symptomatic. VWD is classified in six VWD types (1, 2A, 2B, 2M, 2N, 3) with peculiar phenotype and genotype. The. Von Willebrand disease is the most common hereditary coagulation abnormality. It was first described in Finland in 1926 by Baron Erik von Willebrand, who noted young girls dying of a haemorrhage at puberty and called the condition pseudo-haemophilia. The estimated prevalence is around 1% of the general population Biological findings in Von Willebrand's pedigrees: implications for inheritance. Journal of Clinical Pathology, 1967. Pierre Maroteaux. M. Larrieu. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper

PPT - von Willebrand’s Disease PowerPoint Presentation

Inherited von Willebrand disease is classified into three main types - type I, II, and III. Von Willebrand disease type I is the most common, making up 75 percent of all cases. It is autosomal dominant, meaning that a mutation in only one allele results in insufficient, or even defective production of von Willebrand factor 1 out of 4 children (25%) will have two defective vWF genes, which will result in severe von Willebrand disease. Von Willebrand types I and II have a dominant inheritance pattern. That means that in a child with one normal gene and one gene for either of these von Willebrand types, the defective gene in stronger Type 2A von Willebrand disease is inherited as an autosomal dominant trait and is characterized by normal-to-reduced plasma levels of factor VIIIc (FVIIIc) and von Willebrand factor. Analysis of von Willebrand factor multimers reveals a relative reduction in intermediate and high molecular weight multimer complexes Common Symptoms. Von Willebrand disease type I (VWDI) is an inherited bleeding disorder affecting many breeds of dog. Dogs affected with VWDI have less than half of the normal level of von Willebrand coagulation factor (vWf), which is an essential protein needed for normal blood clotting

von Willebrand Disease (VWD) is one of the most common inherited bleeding disorders worldwide with a prevalence of ~1% of the normal population (Werner et al. 1993) . VWD is caused by defective or deficient von Willebrand Factor (VWF) (Ginsburg et al. 1985). VWF is a large, multimeric glycoprotein that is released into the blood from endothelial cells and platelets and plays a key role in. Desprez D, Drillaud N, Flaujac C, et al. Efficacy and safety of a recombinant von Willebrand factor treatment in patients with inherited von Willebrand disease requiring surgical procedures. Haemophilia. Published online February 6, 2021. doi:10.1111/hae.1424 INTRODUCTION. von Willebrand disease (VWD) is the most common inherited bleeding disorder. Management can vary widely depending on the type of VWD, severity and location of bleeding, and need for invasive procedures

von Willebrand disease Inheritance, Types, Symptoms

Von Willebrand disease (vWD) is the most common inherited bleeding condition. It can also result from leukemia, lupus, and the use of some drugs. A person with vWD will bruise and bleed more. Introduction. Von Willebrand's Disease (vWD) is a type of haemophilia (clotting disorder). It is caused by deficiencies in a protein called von Willebrand factor (vWF), which helps to prolong the life of factor VIII in the clotting cascade.Most cases are relatively mild, and the vast majority probably go undiagnosed Von Willebrand disease (VWD - also known as von Willebrand disorder) is an inherited bleeding disorder. People with VWD have a problem with a protein in their blood called von Willebrand factor (VWF) that helps control bleeding. They do not have enough of the protein or it does not work the way it should Because Von Willebrand disease is divided into three different types there are different possibilities of inheriting the disease. Say you had Von Willebrand disease type 1 or 2 you would easily pass on the disease because it is autosomal dominant. If you had Von Willebrand disease type 3 then you would only be able to pass on the disease if.

von Willebrand disease (VWD; 2019 ICD-10-CM: D68.0) is an inherited bleeding disorder caused by low concentration of or functionally impaired von Willebrand factor (), with an estimated prevalence of approximately 1% of the population. 1,2 VWD affects men and women at the same rate, but women are more often diagnosed because of heavy menstruation, bleeding during pregnancy or bleeding. von Willebrand disease (VWD) is the most common autosomal bleeding disorder, mostly inherited as dominant trait. VWD is due to deficiency/abnormality of von Willebrand factor (VWF). The prevalence of VWD is unknown, but estimated as 0.1% to 1% of the general population. Although the autosomal inheritance pattern would suggest an equal.

VON WILLEBRAND DISEASE – HistopathologyThe Mechanism Of Inheritance Of HemophiliaPPT - Bleeding Disorders Haemostasis Hemorrhage in OralGene Therapy - Irish Haemophilia Society

Co-inheritance of mild hemophilia A and heterozygosity for

Von Willebrand disease (VWD) is an inheritable bleeding disorder. Many different proteins are needed to make a person's blood clot successfully. People with VWD are either missing or low in the clotting protein von Willebrand factor (VWF) - or it doesn't work as it's supposed to. For a person to make a successful clot, VWF binds to. Von Willebrand disease, or vWD, is an inherited bleeding disorder - meaning it's passed from parent to child through genes - that affects the blood's ability to clot properly. It takes its name from Dr. Erik von Willebrand, who first described the condition in 1926. As a group, bleeding disorders (hemophilia) are rare

Von Willebrand disease: MedlinePlus Genetic

Von Willebrand disease (VWD) is a family of bleeding disorders caused by an abnormality of the von Willebrand factor (VWF). VWD is the most common hereditary bleeding disorder. First described by Erik Adolf von Willebrand in 1926, VWD is a congenital bleeding disorder characterized by a lifelong tendency toward easy bruising, frequent epistaxis. Von Willebrand disease (vWD) is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. It is known to affect humans and Continue reading Von Willebrand. Von willebrands disease 1. Von Willebrand Disease Douglas Montgomery MD 7/10/2008 2. What is VWD Most common inherited bleeding disorder affecting ~ 1% of the population Inherited VWD is caused by genetic mutations that lead to decreased production OR impaired function of Von Willebrand Factor (VWF) Acquired VWD is most commonly associated with immunoproliferative cancer and Autoimmune Dz ( SLE

Von Willebrand disease - NH

What is von Willebrand Disease (VWD)? Von Willebrand disease (VWD - also known as von Willebrand disorder) is an inherited bleeding disorder. People with VWD have a problem with a protein in their blood called von Willebrand factor (VWF) that helps control bleeding. They do not have enough of the protein or it does not work the way it should Von Willebrand disease is an inherited bleeding disorder that is caused by deficiency or dysfunction of von Willebrand factor (VWF). VWF is a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury. This protein also binds to clotting factor VIII (FVIII) in the circulation and stabilizes it.. Von Willebrand disease is the most common inherited bleeding disorder, affecting approximately 1% of the population. Von Willebrand factor is a blood protein that binds to factor VIII (a coagulation factor) This test is used to diagnose von Willebrand disease, a bleeding disorder that causes excessive bleeding after minor injuries von Willebrand disease (vWD) is the most commonly inherited hemostatic abnormality in humans 10,22 and dogs. 3,4 The prevalence of vWD in men is 0.82-1.6%, although the incidence could be overestimated because of the difficulties in laboratory diagnosis of this disease. 42 Type I vWD is more frequently diagnosed (60-80%), followed by type II vWD (15-30%), and type III vWD (5-10%). 10.